Restorative effect of Coriolus versicolor polysaccharides against gamma-irradiation-induced spleen injury in mice
Abstract
AIM:
To study the restorative effect of Coriolus versicolor polysaccharides (CVP) on spleen injury induced by gamma-ray irradiation in mice.
METHODS:
ICR Male mice, 6-8 wk old, were divided at random into 3 groups: A) normal control; B) irradiated with 1 Gy; and C) after 1 Gy irradiation, given CVP 60 mg.kg-1 (ig) daily for 10 d continuously. Body weight (BW), spleen weight (SW), relative SW (RSW), DNA synthesis of splenocytes (DNA-SS), and relative DNA-SS were measured on d 5, 12, 19, 26, and 33 after irradiation.
RESULTS:
SW, RSW, DNA-SS, and relative DNA-SS decreased after irradiation. CVP enhanced the recovery of SW, RSW, DNA-SS, and relative DNA-SS inhibited by irradiation.
CONCLUSION:
CVP has the restorative effect against spleen injury induced by gamma-ray irradiation in mice.
Keywords:
To study the restorative effect of Coriolus versicolor polysaccharides (CVP) on spleen injury induced by gamma-ray irradiation in mice.
METHODS:
ICR Male mice, 6-8 wk old, were divided at random into 3 groups: A) normal control; B) irradiated with 1 Gy; and C) after 1 Gy irradiation, given CVP 60 mg.kg-1 (ig) daily for 10 d continuously. Body weight (BW), spleen weight (SW), relative SW (RSW), DNA synthesis of splenocytes (DNA-SS), and relative DNA-SS were measured on d 5, 12, 19, 26, and 33 after irradiation.
RESULTS:
SW, RSW, DNA-SS, and relative DNA-SS decreased after irradiation. CVP enhanced the recovery of SW, RSW, DNA-SS, and relative DNA-SS inhibited by irradiation.
CONCLUSION:
CVP has the restorative effect against spleen injury induced by gamma-ray irradiation in mice.