Original Article

Global depletion of myocardial norepinephrine and ATP after left coronary artery occlusion in rats

Pei Rong, De-Zai Dai, Jiao-E Zhang

Abstract

After ligation of the left coronary artery in rats, myocardial norepinephrine (NE) and ATP depletions in both infarcted (IZ) and non-infarcted zone (NIZ) were studied. In IZ, the depletions of NE and ATP were biphasic and the depleting rate constants were found to be K1 = 0.71 h-1 and K2 = 0.015 h-1 for NE, and K1' = 0.52 h-1 and K2' = 0.016 h-1 for ATP. In NIZ, the depletion of NE was monophasic, slowly progressive, and quite durable with rate constant K3 = 0.018 h-1. The depletion of ATP was transient. Propranolol (Pro) and verapamil (Ver) were beneficial but only partly effective against NE and ATP depletions.
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