A simple method for estimating half-life of drugs obeying Michaelis-Menten elimination kinetics
Abstract
AIM: To establish a simple method for estimating half-life of drugs obeying Michaelis-Menten elimination kinetics.
METHODS: A linear relationship is sketched between elimination half-life and drug concentration in blood that obey Michaelis-Menten elimination kinetics. A simple method is proposed to draw a regression line of blood drug concentration vs time after a single bolus intravenous injection.
RESULTS & CONCLUSION: The elimination half-life can be read from the regression line. The method can also be used to estimate the time required for the plasma concentration of a drug to decrease any fraction.
Keywords:
METHODS: A linear relationship is sketched between elimination half-life and drug concentration in blood that obey Michaelis-Menten elimination kinetics. A simple method is proposed to draw a regression line of blood drug concentration vs time after a single bolus intravenous injection.
RESULTS & CONCLUSION: The elimination half-life can be read from the regression line. The method can also be used to estimate the time required for the plasma concentration of a drug to decrease any fraction.