Antiulcer action and mechanism of trifluoperazine in rat stomach

Trifluoperazine (TFP) 5, 10, 20 mg.kg-1 ig inhibited the formation of gastric ulcers induced by pyloric ligation, stress and indomethacin in rats and showed dose-effect dependence. TFP 10, 20 mg.kg-1 ig depressed the secretion of gastric juice, acid, and pepsin, but TFP 5, 10, 20 mg.kg-1 ig had no influence on the pepsin activity. TFP 20 mg.kg-1 ig inhibited the gastric H+, K(+)-ATPase activity of both stress and indomethacin ulcers in rats in vivo, and the gastric H+, K(+)-ATPase activity was also inhibited by TFP 50 mumol.L-1 in vitro. The results suggested that the inhibition of gastric H+, K(+)-ATPase activity and gastric secretion might be related to the antiulcer mechanism of TFP.