Influence of carbenicillin on pharmacokinetics of ribostamycin in 7 volunteers when they were used combinedly

The experiment consists of two groups, namely the ribostamycin (Rib) group and the Rib and carbenicillin (Car) combination group. There were 7 healthy volunteers in each group. The Rib concentration in blood and urine was detected with the improved microbiology method. The organism tested was Bacillus pumilus. The results demonstrated that the drug serum level was in line with the one-compartment open model. The parameters such as K, Ka, T1/2, T1/2a, Tp, Cmax, and AUC in the Rib group and the combination group were 0.43 +/- 0.03 and 0.41 +/- 0.04 h-1, 3.09 +/- 1.37 and 2.82 +/- 1.48 h-1, 1.61 +/- 0.12 and 1.72 +/- 0.17 h, 0.26 +/- 0.12 and 0.31 +/- 0.15 h, 0.91 +/- 0.20 and 1.01 +/- 0.31 h, 37 +/- 4 and 34 +/- 6 micrograms.ml-1, 123 +/- 17 and 120 +/- 16 micrograms.h.ml-1, respectively. The 24-h urinary recovery rates of the 2 groups were 84 +/- 3% and 84 +/- 5%, respectively. There was no significant difference (P greater than 0.05) between the parameters of the 2 groups. The results indicate that Car has no apparent effect on the pharmacokinetics of Rib in the healthy volunteers.