Clonidine stimulates central nervous alpha 2 adrenoceptors not mediating Ca2+ channels

Seven renal hypertensive (2 kidneys--2 clipped) and 8 normotensive conscious dogs were given icv clonidine. After the medication the mean arterial blood pressure (MAP) were lowered and the heart rate (HR) and plasma norepinephrine (NE) were decreased. The magnitude of the decrease of MAP was greater than normotensive dogs; while no differences of decrease of NE was found. Nicardipine (10 micrograms/kg) icv caused significant increases of MAP and HR in both hypertensive and normotensive groups. The decrease of MAP induced by clonidine was not changed by the pretreatment of nicardipine icv in both groups. It is thus concluded that clonidine stimulates central nervous alpha adrenoceptors not mediating Ca2+ channels.