Electron microscopic observation of the sporogonic stage of Plasmodium gallinaceum after five antimalarials

Ultrastructural changes in Plasmodium gallinaceum oocysts and sporozoites were studies after 5 antimalarials (pyrimethamine, primaquine, artemisinine, 5-p-fluorobenzoxyl-primaquine citrate and nitroquine) were administered to Aedes albopictus. Obvious disfigurement, such as abnormal vacuoles of various sizes in the cytoplasma, thickened oocyst capsules and damaged sporozoite pellical membranes were found in many oocysts and sporozoites in the mosquitoes. When the grade of infection of sporozoites in the salivary glands of the 5 different groups of mosquitoes were compared with the control, the rank test (Hc = 271) showed a very significant variance (P less than 0.01).