Population kinetic program for Michaelis-Menten elimination

The microcomputer program, PKP-ME (population kinetic program for Michaelis-Menten elimination), is presented to estimating population pharmacokinetic parameters of drug obeying Michaelis-Menten kinetics and predicting individual pharmacokinetic parameters. A data set consisting of 69 steady-state phenytoin concentration-dosage pairs from 44 out-patients was analyzed with the present program. Five population kinetic parameters and their standard deviations were given by PKPME. The capability predicting individual phenytoin dosage was assessed by the retrospective analysis of data of 44 patients and the prospective analysis of 15 patients. A good correlation existed between predicting dose and actual dose. Population correlation coefficient was equal to 0.99 at P = 0.05.