Effects of sodium beta-3,4-dihydroxyphenyl lactate and beta-phenyl lactic acid on prostacyclin and thromboxane A2 contents in plasma of rabbits after coronary artery occlusion
Abstract
This paper reports the effects of natural(+) sodium beta-3,4-dihydroxyphenyl lactate[(+)DHPL], synthetic (+/-) DHPL and (+/-)beta-phenyl lactic acid (PLA) on prostacyclin and thromboxane A2 contents in plasma of rabbits after occlusion of descending branch of coronary artery.
PLA and (+)DHPL (50 mg/kg iv) reduced elevation of S-T segment, but (+/-)DHPL (50 mg/kg iv) failed to do so. PLA, (+)DHPL and (+/-) DHPL reduced the production of thromboxane A2; (+)DHPL and (+/-)DHPL reduced prostacyclin production markedly, but PLA had no effect.
These results suggest that the action of PLA might be mainly to inhibit thromboxane synthetase.
Keywords:
PLA and (+)DHPL (50 mg/kg iv) reduced elevation of S-T segment, but (+/-)DHPL (50 mg/kg iv) failed to do so. PLA, (+)DHPL and (+/-) DHPL reduced the production of thromboxane A2; (+)DHPL and (+/-)DHPL reduced prostacyclin production markedly, but PLA had no effect.
These results suggest that the action of PLA might be mainly to inhibit thromboxane synthetase.