Effect of Bupleurum kunmingense polysaccharides on the weight of spleen, thymus, proliferation of lymphocyte and plaque forming cell in mice
Abstract
The Bupleurum kunmingense polysaccharides (BKP) injected ip 50 or 200 mg/kg qd*4 d increased the weight of mouse spleen. BKP ip 50 mg/kg qd * 4 d enhanced the proliferative response of mouse splenocytes to lipopolysaccharides (LPS) but not to ConA as measured by [3H]TdR incorporation. On the other hand, the plaque forming cells (PFC) in 2*10(7) splenocytes of mice treated with BKP were lower than that of control group. These results suggest that BKP has selective activity on immune system.
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