Anti-inflammatory effect of trilobine hydrochloride
Abstract
Trilobine-HCl (TrL) 10 mg/kg ip or 400 mg/kg ig inhibited the edema of hind paw indeced by injection of fresh egg white 0.1 ml or 2.5% formaldehyde 0.1 ml in rats. TrL 10-30 mg/kg ip inhibited the edema of hind paw produced by injection of 0.15 ml carrageenin in normal or adrenalectomized rats. It inhibited the proliferation of granuloma induced by cottonpellet after sc 20 mg/kg qd*7 d. It inhibited the swelling of mouse ear induced by xylene and the increased vascular permeability induced by 0.7% HAc in mice.
TrL did not prolong the surviving time in adrenalectomized rats. It decreased the content of prostaglandin E in inflammatory tissue. It induced marked involution of the thymus, but it increased the weight of adrenal and plasma concentration of cortisol in rats. The anti-inflammatory activity of TrL is presumably due to the inhibition of synthesis or release of prostaglandin E and the increase of ACTH release from the pituitary gland.
Keywords:
TrL did not prolong the surviving time in adrenalectomized rats. It decreased the content of prostaglandin E in inflammatory tissue. It induced marked involution of the thymus, but it increased the weight of adrenal and plasma concentration of cortisol in rats. The anti-inflammatory activity of TrL is presumably due to the inhibition of synthesis or release of prostaglandin E and the increase of ACTH release from the pituitary gland.