Absorption, distribution and excretion of 3-methyl[carbonyl-14C]fentanyl in mice
Abstract
3-methyl[carbonyl-14C]fentanyl sc was rapidly absorbed into the blood. The radioactivities in blood, lung heart and brain reached the maximum 10 min after sc. The radioactivities in the kidney, liver and fat increased markedly 30 min after sc and reached their maximum 1 h after sc. Ten min after sc, the lung showed the highest concentration among the organs, the following were heart, kidney, brain, liver and fat. The radioactivities decreased markedly after 24 h. Within 48 h, the excreted radioactivities in urine and feces were 61.7% and 13.8%, respectively of the total administered amount.
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