Effects of quinamic acid on cadmium distribution and excretion in mice and rats
Abstract
Quinamic acid, bis(3-carboxy-5-N-dicarboxymethylaminomethyl-6,7- dihydroxy-1,2,3,4-tetrahydroisoquinolinyl-8)-5,8-dimethyl-6,7-dihydroxy-l,2,3,4- tetrahydroisoquinoline-3-carboxylie acid, is a new polyaminocarboxylic acids chelating agent. It was first synthesized in this institute.
Quinamic acid ip 500 mg/kg after iv 109CdCl2 in mice, reduced the cadmium contents in the liver and the brain (p<0.05), and increased the excretion of cadmium in urine about 17 times more than the control group within 24 h. The cadmium excretion of the 109CdCl2 poisoning rats immediately im quinamic acid were about 30 times in urine and the cadmium 2.2 times in bile the control within 8 h. The sephadex G-75 chromatogram of 1.5 h urine and 2 h bile showed two peaks after iv109CdCl2 1.48 MBq and im the chelating agent, the A peak was considered as a high mol wt of macromolecule complex, and the B peak was quinamic acid and cadmium complex possessing the same position in vivo and in vitro.
Keywords:
Quinamic acid ip 500 mg/kg after iv 109CdCl2 in mice, reduced the cadmium contents in the liver and the brain (p<0.05), and increased the excretion of cadmium in urine about 17 times more than the control group within 24 h. The cadmium excretion of the 109CdCl2 poisoning rats immediately im quinamic acid were about 30 times in urine and the cadmium 2.2 times in bile the control within 8 h. The sephadex G-75 chromatogram of 1.5 h urine and 2 h bile showed two peaks after iv109CdCl2 1.48 MBq and im the chelating agent, the A peak was considered as a high mol wt of macromolecule complex, and the B peak was quinamic acid and cadmium complex possessing the same position in vivo and in vitro.