Effects of ginseng root saponins on central transmitters and plasma corticosterone in cold stress mice and rats
Abstract
The effects of ginseng root saponins (GRS) on the rectal temperature, plasma corticosterone and central transmitters were studied using mice and rats subjected to a cold stress. When mice were put in - 2°C environment for 1 h, the rectal temperature fell significantly. While ig GRS 50 or 100 mg/kg caused a slow fall in rectal temperature of mice in the same condition. The contents of brain NE, 5-HT, 5-HIAA were decreased in mice in -4°C environment for 1 h, and increased in mice after ig GRS 100 mg/kg. But DA showed no change both in cold stress and GRS groups.
When rats were put in -2°C for 1 h, the rectal temperature also fell markedly, the plasma corticosterone increased. While ig GRS 70 mg/kg, the rectal temperature showed no change, the brain ACh and plasma corticosterone increased apparently, but there was no change in brain GABA, Glu and Asp.
Keywords:
When rats were put in -2°C for 1 h, the rectal temperature also fell markedly, the plasma corticosterone increased. While ig GRS 70 mg/kg, the rectal temperature showed no change, the brain ACh and plasma corticosterone increased apparently, but there was no change in brain GABA, Glu and Asp.