Effects of dimethyltrilobine iodide on isolated superior cervical ganglion of rabbits
Abstract
The effects of dimethyltrilobine iodide (DTI) were studied by the sucrose-gap method using curare for comparison. DTI at cumulative concentration inhibited ganglion action potentials. IC50 of DTI and curare were 82 and 30 μg/ml, respectively. The effects of DTI were antagonized by neostigmine, enhanced under Ca2+-free or 1/2[Ca2+] and reduced under 2[Ca2+]. DTI inhibited ganglionic N wave, P wave and LN wave.
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