Effect of sodium ferulate on malondialdehyde production from platelets of rats
Abstract
Sodium ferulate (SF) 0.5 and 1 mg/ml exhibited inhibitory effect on rat platelet malondialdehyde (MDA) production induced by arachidonic acid. Sodium ferulate 0.2 and 1.0 mg/ml inhibited both platelet aggregation and platelet MDA formation induced by collagen. Intragastrical gavage with SF 600 mg/kg inhibited platelet MDA formation. These results indicated that the inhibitory effect of SF on platelet aggregation and release reaction may be due to the inhibition of platelet prostaglandin metabolism or TXA2 formation.
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