Immunopotentiating effects of oxalysine
Abstract
L-4-Oxalysine is an antibiotic agent isolated from a new species of Streptomyces roseoviridofuscus n. sp. in China. It inhibited the growth of several kinds of animal transplanted tumors and protected liver injuries from CCl intoxications. Clinical trials showed improvement of liver function as well as liver blood flow in patients of chronic viral hepatitis.
Oxalysine 100 mg/kg ip or ig administration to C 57/BL mice caused a marked increase of spleen plaque forming cells as well as serum hemolysin and IgG levels. Serum complement C 3 is also increased. Oxalysine 50 and 100 mg/kg ip for 3 d or 100 mg/kg ig for 5 d promoted the incorporation rate of [3H]TdR into spleen lymphocytes but showed no direct stimulating effect on lymphocyte blastogenesis in vitro. Oxalysine also elevated the SRBC induced delayed-type hypersensitivity on ICR mice, but had no effect on the phagocytic activity of macrophages. It is therefore considered that oxalysine has the ability of potentiating both humoral and cell mediated immunological responses, which is benefit jn ameliorating the immuno-deficient condition in patients suffered with cancer or chronic viral hepatitis.
Keywords:
Oxalysine 100 mg/kg ip or ig administration to C 57/BL mice caused a marked increase of spleen plaque forming cells as well as serum hemolysin and IgG levels. Serum complement C 3 is also increased. Oxalysine 50 and 100 mg/kg ip for 3 d or 100 mg/kg ig for 5 d promoted the incorporation rate of [3H]TdR into spleen lymphocytes but showed no direct stimulating effect on lymphocyte blastogenesis in vitro. Oxalysine also elevated the SRBC induced delayed-type hypersensitivity on ICR mice, but had no effect on the phagocytic activity of macrophages. It is therefore considered that oxalysine has the ability of potentiating both humoral and cell mediated immunological responses, which is benefit jn ameliorating the immuno-deficient condition in patients suffered with cancer or chronic viral hepatitis.