Effects of scopolamine plus atropine on experimental myocardial infarction of rabbits
Abstract
Experimental acute myocardial infarction was produced by high positioned double-ligation of anterior descending branch of left coronary artery, and the influence of scopolamine 1.2 mg+atropine 0.4 mg/kg and propranolol 2 mg/kg were estimated by precardial ECG mapping and plasma cAMP and cGMP measuring and macroscopic identification after nitrotetrazolium blue staining.
The weight of infarction sizes, the height of S-T segment elevations, the number of S-T elevating leads and pathologic Q waves were decreased in the group treated with scopolamine+atropine for 3 d (all results were compared with control, p<0.01). The plasma cAMP concentrations in 2 groups treated by saline and propranolol were increased 1 d and 3 d (p<0.05 or 0.01) after ligation, the group treated by scdpolamine+atropine was increased on d l (p<0.01) and was restored on d 3. The plasma cGMP concentrations in 3 groups declined on d 1 (p<0.05 or 0.0l) and recovered on d 3.
This experiment showed that the therapeutic efficacy of scopolamine+atropine was better than that of saline and propranolol.
Keywords:
The weight of infarction sizes, the height of S-T segment elevations, the number of S-T elevating leads and pathologic Q waves were decreased in the group treated with scopolamine+atropine for 3 d (all results were compared with control, p<0.01). The plasma cAMP concentrations in 2 groups treated by saline and propranolol were increased 1 d and 3 d (p<0.05 or 0.01) after ligation, the group treated by scdpolamine+atropine was increased on d l (p<0.01) and was restored on d 3. The plasma cGMP concentrations in 3 groups declined on d 1 (p<0.05 or 0.0l) and recovered on d 3.
This experiment showed that the therapeutic efficacy of scopolamine+atropine was better than that of saline and propranolol.