Effect of cyclophosphamide on serum complement in mice
Abstract
"Cyclophosphamide (CY) 70 mg/kg ip into C57BL inbred mice caused a marked increase in serum C3 level determined by both radial immunodiffusion and rocket Immunoelectrophoresis. The elevation of C3 sustained for 6 d. Cobra venom (1 mg/kg) jp induced depletion of serum C3 which remained low for 4 d； CY accelerated the biosynthesis of C3, so that normal C3 levels were reached within 3 d.
It has been considered that complement plays a major role in the clearance of immune complexes. Increasing serum complement level, inhibiting the production of serum specific antibody-hemolysin and enhancing the phagocytosis of reticuloendothelial system by CY, as shown in this study, may be an important mechanism in its treatment of some auto-immune and immune complex diseases."
Keywords:
It has been considered that complement plays a major role in the clearance of immune complexes. Increasing serum complement level, inhibiting the production of serum specific antibody-hemolysin and enhancing the phagocytosis of reticuloendothelial system by CY, as shown in this study, may be an important mechanism in its treatment of some auto-immune and immune complex diseases."