Effect of praziquantel on mice immunity in early stage after infection with Schistosoma japonicum cercariae1
Abstract
When BABI/C mice, infected with about 300 Schistosoma japonicum cercariae for 3 h, were given intragastrically with praziquantel at a single dose of 400 mg/kg, the phagocytosis of their peritoneal macrophages increased significantly within 2-72 h after the medication. The proliferative response of splenic lymphocytes induced by PHA and Con A increased at 72 h after the treatment. This increase in stimulation index of lymphocytes to PHA and Con A occurred also in uninfected BABL/C mice treated with the same dose of praziquantel. No effect of praziquantel on total serum complement content of BABL/C mice was observed.
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