Effect of malnutrition on chloramphenicol kinetics in Indian children
Abstract
Pharmacokinetics of chloramphenicol was studied in 8 malnourished and 4 normal children. After an oral dose of chloramphenicol 50 mg/kg, malnutrition reduced the elimination half-life and the area under the time-concentration curve. But malnutrition exerted no effect on absorption kinetics, Cmax, and tmax.
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