Effects of henbane drugs on thermotropic transition behavior of phospholipid membrane

The effects of anisodamine, atropine, scopolamine and anisodine on the thermotropic transition behavior of dipalmitoylphosphatidic acid (DPPA) membrane were studied by differential scanning calorimetry (DSC). The membrane fluidity was increased by the drugs in a dose-dependent manner. The effects of the henbane drugs on acid phospholipid liposomes were more marked than on the neutral phospholipid dipalmitoyl phosphatidylcholine (DPPC) membrane. Phase separation was seen on the DSC curves of DPPA membrane under the effects of above-mentioned drugs. The order of the efficacies of these 4 drugs on DPPA membrane fluidity was similar to that on the DPPC membrane: anisodamine>atropine>scopolamine>anisodine.