Absorption, distribution and excretion of 3H.kakuol in mice and rats

[3H]Kakuol given intragastrically was rapidly absorbed from gut of mice and rats. It was rapidly taken up by various organs,and has a strong affinity for tissues. The highest radioactivity was found in liver(12.1 time as much as in plasma), followed by heart, spleen, pancreas, kidney, lung and brain. The radioactivity in organs disappeared slowly. In 21 d, cumulative excretion of radioactivity was 92.8% of the total dose in urine and 1.2% in feces. The results measured by TLC autoradiography and liquid scintillation counting in urine indicated that[3H] kakuol was excreted mainly in urine in unchanged form. The rate of binding with plasma protein was 39%. After iv in mice, the decline of radioactivity in the plasma showed a biphasic curve. Pharmacokinetic parameters:t(1/2 alpha)=0.21 h, t(1/2 beta)=40 h, Vc=2.3 L/kg, Vd=26.5 L/kg.