Analysis of anti-arrhythmic activity of cimetidine in anesthetized guinea pigs
Abstract
In anesthetized guinea pigs, iv cimetidine (CMT) 1.12, 2.25, 4.5 mg/kg/min and iv diphenhydramine (DPH) 170 microg/kg/min increased the dose of aconitine required to induce arrhythmia and death; Iv histamine 20 microg/kg/min enhanced the arrhythmic action of aconitine and abolished the anti-arrhythmic effect of CMT, but failed to influence that of DPH. The results indicate that the action of CMT on aconitine-induced arrhythmia in guinea pigs may be mediated via cardiac H2 receptors, whereas that of DPH may be resulted from its membrane-stablizing effects.
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