Effects of histamine and cimetidine on chloride secretion in isolated monkey gastric mucosa
Abstract
The stripped gastric mucosa of Rhesus monkeys were used to study electrical properties and chloride secretion. A potential difference(PD) across the mucosal membrane was seen with serosa being electropositive. The magnitude of PD and short-circuit current(ISC)were found to be close to that of dog gastric mucosa.At resting state, Cl- was secreted from serosal to mucosal side, and this secretion was greatly stimulated by histamine. Cimetidine completely blocked the stimulating effect of histamine on Cl-secretion.
Keywords: