Effects of ginseng root saponins on central transmitters and plasma corticosterone in warm-stress rats
Abstract
Ginseng root saponins (GRS) ip 70 mg/kg apparently diminished the level of GABA in the brain at 20 degrees in rats, but had no effect on Glu and Asp.
The rectal temperature of stress-rat was raised after incubated 20 min in 45 degrees chamber, at the same time the level of Ach in the brain was diminished, GABA and Glu were increased, the level of Asp showed no obvious change, while plasma corticosterone was apparently increased.
At 45 degrees, after ip GRS 100 mg/kg the rectal temperature of stress-rat was apparently lower than that of control, the level of brain Ach was increased, and the plasma corticosterone was increased 3 times as the control, he brain GABA, GLU, and Asp had no change.
Keywords:
The rectal temperature of stress-rat was raised after incubated 20 min in 45 degrees chamber, at the same time the level of Ach in the brain was diminished, GABA and Glu were increased, the level of Asp showed no obvious change, while plasma corticosterone was apparently increased.
At 45 degrees, after ip GRS 100 mg/kg the rectal temperature of stress-rat was apparently lower than that of control, the level of brain Ach was increased, and the plasma corticosterone was increased 3 times as the control, he brain GABA, GLU, and Asp had no change.