Releasing effect of thymidine on G1 phase arrest of erythroleukemia cells caused by FUDR and HMBA
Abstract
In vitro experiments with synchronized MELC, FUDR plus HMBA produced a complete blockade of G1 phase cells. Thymidine at 0.1mM released such a blockade and made the induction of differentiation by HMBA reappearing. Thymidine also released the arrest of G1 cells caused by FUDR +actinomycin D or sodium butyrate.
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