Effect of gamma-schisandrin on metabolism of DNA, ATP and nucleoprotein of cancer cells
Abstract
By means of [3H] thymidine incorporation method, after incubation for 42 h in vitro, the DNA synthesis of ascetic hepatoma, S180-V cells in mice and human embryo lung fibroblast cells were inhibited by γ-schisandrin 99μg/ml for 12,24,36 and 48 h, the nucleoprotein of ascetic hepatoma cells extracted by barium acetate were inhibited 12%, 30%, 37% and 33% , and their ATP isolated by electrophoresis 56%, 58%, 50% and 66%, respectively.
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