Histochemical studies on the effect of furapyrimidone on Litomosoides carinii in cotton rats
Abstract
Cotton rats infected with were treated intragastrically with furapyrimidone 15 mg/kg/d×7 d. The histochemical changes of the worms were observed.
The contents of glycogen, RNA, DNA, alkaline protein, protein-boundα-amino groups, protein-bound tyrosine, tryptophan, histidine, SH groups, phenol substance, the activities of ATPase and AKP in the filariae or microfilariae showed a decrease 3 d after the initiation of treatment. Some of them were markedly decreased or even disappeared 7 d after the initiation of treatment. On the contrary, the activity of ACP was higher than that in the control.
There was no recovery even 7 d after the completion of the treatment.
Keywords:
The contents of glycogen, RNA, DNA, alkaline protein, protein-boundα-amino groups, protein-bound tyrosine, tryptophan, histidine, SH groups, phenol substance, the activities of ATPase and AKP in the filariae or microfilariae showed a decrease 3 d after the initiation of treatment. Some of them were markedly decreased or even disappeared 7 d after the initiation of treatment. On the contrary, the activity of ACP was higher than that in the control.
There was no recovery even 7 d after the completion of the treatment.