Effect of l-tetrahydropalmatine on sleep-waking cycle of cats
Abstract
After ip l-THP 30 to 80 mg/kg in cats, SWS-2, PS and PGO discharges were eliminated. At 80 mg/kg, l-THP interrupted the sleep waking cycle by inducing a notable state of excitation, which lasted 12-30 h. At 30 or 40 mg/kg, the effect of l-THP lasted 10 h; waking was decreased and SWS-1 increased with sedation, but the arousal response was maintained. This effect at 30 or 40 mg/kg is similar to that shown by other tranquillizing drugs or DA-receptor antagonists.
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