No physical dependence of skimmianine in mice, rats and monkeys
Abstract
In mice, ip skimmianine 150 or 215 mg/kg exhibited a sedative effect, while ip morphine 15 mg/kg caused a significant Straub’s tail reaction and motor activity. No tolerance to skimmianine was found in mice. In 2-day test the mice received 7 ip injections of skimmianine or morphine, followed by ip phine 50 mg/kg. Marked jumping was precipitated with nalorphine after morphine, but not with nalorphine after skimmianine (210—300 mg/kg).
Rats were given sc morphine 25 mg/kg bid×120 d. Withdrawal of morphine was followed by a decrease in body wt, which was used as a parameter of abstinence syndrome. Skimmianine ip 80 mg/kg did not alter the loss of body wt of morphine-treated rats.
Two monkeys developed physical dependence after sc morphine of which the daily dose was increased progressively from 2.5 to 25 mg/kg in 21 d and then maintained for 100 d. Skimmianine 20, 30 or 60 mg/kg did not suppress the withdrawal signs evoked by ip nalorphine 2 mg/kg or withdrawal of morphine. These data suggest that skimmianine is a non-narcotic analgesic.
Keywords:
Rats were given sc morphine 25 mg/kg bid×120 d. Withdrawal of morphine was followed by a decrease in body wt, which was used as a parameter of abstinence syndrome. Skimmianine ip 80 mg/kg did not alter the loss of body wt of morphine-treated rats.
Two monkeys developed physical dependence after sc morphine of which the daily dose was increased progressively from 2.5 to 25 mg/kg in 21 d and then maintained for 100 d. Skimmianine 20, 30 or 60 mg/kg did not suppress the withdrawal signs evoked by ip nalorphine 2 mg/kg or withdrawal of morphine. These data suggest that skimmianine is a non-narcotic analgesic.