Immunological activity of bagasse polysaccharides
Abstract
Bagasse polysaccharides injected ip into C57BL inbred mice caused a marked increase in spleen weight, and antagonized the immunosuppressive actions of prednisolone and cyclophosphamide. Dextran ip in equimolecular doses showed no significant effects.
Bagasse polysaccharides injected ip or ig into mice irradiated by deep X-ray prolonged signficicantly the survival time. Bagasse polysaccharides also protected the mice from CCl4 intoxication.
Bagasse polysaccharides given ip increased the clearance rate of iv charcoal particles, i.e., stimulated the phagocytic activity of macrophages. Therefore, it enhanced the functions of reticuloendothelial system.
These polysaccharides had no definite influence on graft versus host reaction (GVHR), nor on serum hemolysin in mice.
The electron microscopic studies of the immunity organs indicated that bagasse polysaccharides given ip 25 mg/kg for 3 days stimulated some membraneous organelles in the cytoplasm, as shown by increases and dilatations of endoplasmic reticulum, especially rough endoplasmic reticulum, Golgi bodies and lysosomes. Sometimes the number of mitochondria and ribosome were increased too.
Keywords:
Bagasse polysaccharides injected ip or ig into mice irradiated by deep X-ray prolonged signficicantly the survival time. Bagasse polysaccharides also protected the mice from CCl4 intoxication.
Bagasse polysaccharides given ip increased the clearance rate of iv charcoal particles, i.e., stimulated the phagocytic activity of macrophages. Therefore, it enhanced the functions of reticuloendothelial system.
These polysaccharides had no definite influence on graft versus host reaction (GVHR), nor on serum hemolysin in mice.
The electron microscopic studies of the immunity organs indicated that bagasse polysaccharides given ip 25 mg/kg for 3 days stimulated some membraneous organelles in the cytoplasm, as shown by increases and dilatations of endoplasmic reticulum, especially rough endoplasmic reticulum, Golgi bodies and lysosomes. Sometimes the number of mitochondria and ribosome were increased too.