Uterine contraction and pyrogenic action of yuanhuacine
Abstract
Yuanhuacine is a new diterpenoid isolated from Daphne genkwa. Rats (0.3 kg) and guinea pigs (0.6-0.8 kg) were used. Effects of yuanhuacine (0.01 microg/ml) on isolated uteri in vitro and yuanhuacine (intra-uterine 100 microg/kg) on uteri in situ were studied. The uterine contractions were all augmented, stronger in uterine bodies and pregnant uteri than in uterine Cervis and non-pregnant uteri. No augmentation was seen after iv 100 microg/kg in rabbits.
The rectal temperature of guinea pigs rose 0.90+/-0.06 degrees after intra-uterine injection of yuanhuacine 50 microg/kg. The temperature of rabbits rose 0.80+/-0.06 degrees after iv 100 microg/kg, and rose 1.05+/-0.10 degrees after yuanhuacine was injected 100-200 microg/kg into the subcutaneous “granuloma pouch”. Intragastric gavage of acetylsalicylic acid in rabbits prevented the pyrogenic action. The sera of febrile rabbits contained certain endogenous pyrogens which were destroyed by pepsin.
Keywords:
The rectal temperature of guinea pigs rose 0.90+/-0.06 degrees after intra-uterine injection of yuanhuacine 50 microg/kg. The temperature of rabbits rose 0.80+/-0.06 degrees after iv 100 microg/kg, and rose 1.05+/-0.10 degrees after yuanhuacine was injected 100-200 microg/kg into the subcutaneous “granuloma pouch”. Intragastric gavage of acetylsalicylic acid in rabbits prevented the pyrogenic action. The sera of febrile rabbits contained certain endogenous pyrogens which were destroyed by pepsin.