Determination of nevadensin in biological specimens and its pharmacokinetic study
Abstract
A method was developed for the isolation of nevadensin (5, 7-dihydroxy-4’,6,8-trimethoxyflavone) from biological specimens and its quantitative determination by polyamide TLC and UV spectrophotometry. By means of this method analysis of pharmacokinetic characteristics of the drug in rats, dogs, and monkeys was made.
Patterns of decline of the plasma level of the drug in these animals after iv and ig confer upon the body the characteristics of the two-compartment open model.
Kinetic analysis indicated that nevadensin was distributed fairly rapidly, and eliminated rather quickly. The absorption of ig nevadensin in suspension was very poor. However, when given in aqueous solution, the absorption was fairly rapid, but its bioavailability was low.
Keywords:
Patterns of decline of the plasma level of the drug in these animals after iv and ig confer upon the body the characteristics of the two-compartment open model.
Kinetic analysis indicated that nevadensin was distributed fairly rapidly, and eliminated rather quickly. The absorption of ig nevadensin in suspension was very poor. However, when given in aqueous solution, the absorption was fairly rapid, but its bioavailability was low.