Antiarrhythmic action of tetrandrine and the total alkaloids of sophora flavescens
Abstract
The antiarrhythmic acitons of the alkaloids of Sophora flavescens (AP) and tetrandrine (T), an alkaloid isolated from Stephania tetrandra S. Moore, were studied, with diphenylhydantoin sodium (DPH) as the standard drug for comparison.
It was found that T was able to counteract the ventricular fibrillation in cats after administration of chloroform and adrenaline. AP showed slightly weaker action.
The order of antiarrhythmic effectiveness in aconitine-induced arrhythmia in rats was DPH>AP>T, and in ouabain-induced arrhythmia in guinea pigs was DPH>T>>AP.
Keywords:
It was found that T was able to counteract the ventricular fibrillation in cats after administration of chloroform and adrenaline. AP showed slightly weaker action.
The order of antiarrhythmic effectiveness in aconitine-induced arrhythmia in rats was DPH>AP>T, and in ouabain-induced arrhythmia in guinea pigs was DPH>T>>AP.