Effects of dimethyl cycleanine bromide on cardiac hemodynamics of anesthetized dogs

In 6 anesthetized dogs, cardiac output was estimated by Fick’s principle. Intravenous injection of dimethyl cycleanine bromide 0.8 mg/kg produced a diminution of arterial blood pressure, heart rate, cardiac output, left ventricular work and total peripheral resistance. But the stroke volume remained unchanged. In another 4 dogs, the blood flows of carotid and femoral arteries were measured with electromagnetic flowmeter. Intravenous injections of 0.8 mg/kg resulted in a hypotension associated with a reduction of the carotid and femoral blood flows. The carotid and femoral vasvular resistances were reduced slightly. It was suggested that the hypotensive effect was due to a reduction of both cardiac output and peripheral resistance.