Effects of orexins on myoelectric activity of sphincter of Oddi in fasted rabbits
Abstract
Aim: To investigate the effects of peripheral orexins on myoelectric activity of the
sphincter of Oddi (SO) in fasted rabbits, and carry out a preliminary investigation
into the mechanisms underlying these effects. Methods: Myoelectric activity of
SO in fasted rabbits was recorded before and after intravenous or local application
of orexins. The effects of intravenous atropine on orexin-increased myoelectric
activity of SO were tested. Results: Myoelectric activity of SO was activated by
both intravenous and local injection of orexin-A or orexin-B. Intravenous application
of atropine completely inhibited the excitatory effect of orexins on SO.
Conclusion: Peripheral application of orexins can increase myoelectric activity of
SO in fasted rabbits, which is partially associated with the activation of the cholinergic
pathway.
Keywords:
sphincter of Oddi (SO) in fasted rabbits, and carry out a preliminary investigation
into the mechanisms underlying these effects. Methods: Myoelectric activity of
SO in fasted rabbits was recorded before and after intravenous or local application
of orexins. The effects of intravenous atropine on orexin-increased myoelectric
activity of SO were tested. Results: Myoelectric activity of SO was activated by
both intravenous and local injection of orexin-A or orexin-B. Intravenous application
of atropine completely inhibited the excitatory effect of orexins on SO.
Conclusion: Peripheral application of orexins can increase myoelectric activity of
SO in fasted rabbits, which is partially associated with the activation of the cholinergic
pathway.