Review Article

ARID3a from the ARID family: structure, role in autoimmune diseases and drug discovery

Cheng-cen Guo1, H. Eric Xu2,3,4, Xiong Ma1
1 Department of Gastroenterology and Hepatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute of Digestive Disease, Shanghai 200001, China
2 State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
3 University of Chinese Academy of Sciences, Beijing 100049, China
4 School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China
Correspondence to: Cheng-cen Guo: guochengcen@163.com, H. Eric Xu: eric.xu@simm.ac.cn, Xiong Ma: maxiongmd@hotmail.com,
DOI: 10.1038/s41401-023-01134-2
Received: 13 March 2023
Accepted: 9 July 2023
Advance online: 24 July 2023

Abstract

The AT-rich interaction domain (ARID) family of DNA-binding proteins is a group of transcription factors and chromatin regulators with a highly conserved ARID domain that recognizes specific AT-rich DNA sequences. Dysfunction of ARID family members has been implicated in various human diseases including cancers and intellectual disability. Among them, ARID3a has gained increasing attention due to its potential involvement in autoimmunity. In this article we provide an overview of the ARID family, focusing on the structure and biological functions of ARID3a. It explores the role of ARID3a in autoreactive B cells and its contribution to autoimmune diseases such as systemic lupus erythematosus and primary biliary cholangitis. Furthermore, we also discuss the potential for drug discovery targeting ARID3a and present a plan for future research in this field.
Keywords: transcription factors; ARID; ARID3a; autoimmune diseases; systemic lupus erythematosus; primary biliary cholangitis

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