Review Article

A new glance at autophagolysosomal-dependent or -independent function of transcriptional factor EB in human cancer

Ting Wang1,2,3,4,5, Yi Qin1,2,3,4,5, Zeng Ye1,2,3,4, De-sheng Jing1,2,3,4, Gui-xiong Fan1,2,3,4, Meng-qi Liu1,2,3,4, Qi-feng Zhuo1,2,3,4, Shun-rong Ji1,2,3,4, Xue-min Chen5, Xian-jun Yu1,2,3,4, Xiao-wu Xu1,2,3,4, Zheng Li1,2,3,4
1 Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China
2 Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China
3 Shanghai Pancreatic Cancer Institute, Shanghai 200032, China
4 Pancreatic Cancer Institute, Fudan University, Shanghai 200032, China
5 Department of Hepatobiliary Surgery, The Third Affiliated Hospital of Soochow University, Changzhou 213000, China
Correspondence to: Xian-jun Yu: yuxianjun@fudanpci.org, Xiao-wu Xu: xuxiaowu@fudanpci.org, Zheng Li: lizheng@fudanpci.org,
DOI: 10.1038/s41401-023-01078-7
Received: 27 October 2022
Accepted: 14 March 2023
Advance online: 3 April 2023

Abstract

Autophagy-lysosome system plays a variety of roles in human cancers. In addition to being implicated in metabolism, it is also involved in tumor immunity, remodeling the tumor microenvironment, vascular proliferation, and promoting tumor progression and metastasis. Transcriptional factor EB (TFEB) is a major regulator of the autophagy-lysosomal system. With the in-depth studies on TFEB, researchers have found that it promotes various cancer phenotypes by regulating the autophagolysosomal system, and even in an autophagy-independent way. In this review, we summarize the recent findings about TFEB in various types of cancer (melanoma, pancreatic ductal adenocarcinoma, renal cell carcinoma, colorectal cancer, breast cancer, prostate cancer, ovarian cancer and lung cancer), and shed some light on the mechanisms by which it may serve as a potential target for cancer treatment.
Keywords: neoplasm; autophagy-lysosomal system; TFEB Protein; Mammalian Target Of Rapamycin Complex 1; tumor progression; metastasis

Article Options

Download Citation

Cited times in Scopus

Share