Review Article

Formyl peptide receptor 2 as a potential therapeutic target for inflammatory bowel disease

Wen-sheng Yang1, Jing-lin Wang2, Wei Wu1, Guang-fei Wang1, Jun Yan3, Qing Liu4,5, Xiao-yan Wu4,5, Qing-tong Zhou5,6, De-hua Yang4,5, Ming-Wei Wang5,6, Zhi-ping Li1
1 Department of Pharmacy, Children’s Hospital of Fudan University, National Children’s Medical Center, Shanghai 201102, China
2 Department of Pharmacy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
3 Department of Laboratory Animal Science, Fudan University, Shanghai 200032, China
4 The National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
5 Research Center for Deepsea Bioresources, Sanya 572025, China
6 Department of Pharmacology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China
Correspondence to: Ming-Wei Wang: mwwang@simm.ac.cn, Zhi-ping Li: zpli@fudan.edu.cn,
DOI: 10.1038/s41401-022-00944-0
Received: 22 April 2022
Accepted: 15 June 2022
Advance online: 15 July 2022

Abstract

Inflammatory bowel disease (IBD) is a global health burden whose existing treatment is largely dependent on anti-inflammatory agents. Despite showing some therapeutic actions, their clinical efficacy and adverse events are unacceptable. Resolution as an active and orchestrated phase of inflammation involves improper inflammatory response with three key triggers, specialized pro-resolving mediators (SPMs), neutrophils and phagocyte efferocytosis. The formyl peptide receptor 2 (FPR2/ALX) is a human G protein-coupled receptor capable of binding SPMs and participates in the resolution process. This receptor has been implicated in several inflammatory diseases and its association with mouse model of IBD was established in some resolution-related studies. Here, we give an overview of three reported FPR2/ALX agonists highlighting their respective roles in pro-resolving strategies.
Keywords: resolution; inflammation; FPR2/ALX; SPM; IBD; pro-resolving

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