Beyond iron deposition: making sense of the latest evidence on ferroptosis in Parkinson’s disease
Hai-ying Zhu1,
Qiao-jun He1,2,3,
Bo Yang1,2,
Ji Cao1,2,3
1 Institute of Pharmacology and Toxicology, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China
2 Innovation Institute for Artificial Intelligence in Medicine, Zhejiang University, Hangzhou, China
3 Cancer center of Zhejiang University, Hangzhou, China
Correspondence to: Ji Cao: caoji88@zju.edu.cn,
DOI: 10.1038/s41401-020-00555-7
Received: 28 July 2020
Accepted: 8 October 2020
Advance online: 19 November 2020
Abstract
Parkinson’s disease (PD) is one of the most common neurodegenerative diseases. Here, we suggest that beyond iron deposition, emerging evidence further supports the involvement of ferroptosis in PD. A detailed understanding of ferroptosis in PD will help to predict the onset and progression of disease and establish personalized treatments.
Keywords:
