APS (Acta Pharmacologica Sinica), published monthly in English, is an international peer-reviewed journal. With the leading by Professor Jian Ding, Editor-in-Chief, and the support from a respected global editorial board, APS is continuously growing to a high-level journal in the area of pharmacology and related life sciences. We owe all the journal progress to our authors, reviewers, and guest editors. To acknowledge their fine contributions to the journal, we set awards to outstanding papers, reviewers, and guest editors.
APS Outstanding Paper Award
Shikonin induces glioma cell necroptosis in vitro by ROS overproduction and promoting RIP1/RIP3 necrosome formation
Bin Lu, Xu Gong, Zong-Qi Wang, Ye Ding, Chen Wang, Tian-Fei Luo, Mei-Hua Piao, Fan-Kai Meng, Guang-Fan Chi, Yi-Nan Luo, Peng-Fei Ge
Acta Pharmacol Sin. 2017 Nov; 38(11):1543-1553. doi: 10.1038/aps.2017.112. Epub 2017 Aug 17.
The ceramide pathway is involved in the survival, apoptosis and exosome functions of human multiple myeloma cells in vitro
Qian Cheng, Xin Li, Yue Wang, Min Dong, Feng-Huang Zhan, Jing Liu
Acta Pharmacol Sin. 2018 Apr; 39(4):561-568. doi: 10.1038/aps.2017.118. Epub 2017 Aug 31.
Astragaloside IV attenuates free fatty acid-induced ER stress and lipid accumulation in hepatocytes via AMPK activation
Bing Zhou, Dan-Li Zhou, Xiao-Hong Wei, Rong-Yu Zhong, Jie Xu, Liao Sun
Acta Pharmacol Sin. 2017 Jul; 38(7):998-1008. doi: 10.1038/aps.2016.175. Epub 2017 Mar 27.
SIRT1 plays a neuroprotective role in traumatic brain injury in rats via inhibiting the p38 MAPK pathway
Hong Yang, Zheng-Tao Gu, Li Li, Mac Maegele, Bi-Ying Zhou, Feng Li, Ming Zhao, Ke-Sen Zhao
Acta Pharmacol Sin. 2017 Feb; 38(2):168-181. doi: 10.1038/aps.2016.130. Epub 2016 Dec 26.
Molecular design and synthesis of self-assembling camptothecin drug amphiphiles
Andrew G Cheetham, Yi-An Lin, Ran Lin, Honggang Cui
Acta Pharmacol Sin. 2017 Jun; 38(6):874-884. doi: 10.1038/aps.2016.151. Epub 2017 Mar 6.
Insights into the molecular mechanisms of Polygonum multiflorum Thunb-induced liver injury: a computational systems toxicology approach
Yin-Yin Wang, Jie Li, Zeng-Rui Wu, Bo Zhang, Hong-Bin Yang, Qin Wang, Ying-Chun Cai, Gui-Xia Liu, Wei-Hua Li, Yun Tang
Acta Pharmacol Sin. 2017 May;38(5):719-732. doi: 10.1038/aps.2016.147. Epub 2017 Feb 27.
The Chk1 inhibitor MK-8776 increases the radiosensitivity of human triple-negative breast cancer by inhibiting autophagy
Zhi-Rui Zhou, Zhao-Zhi Yang, Shao-Jia Wang, Li Zhang, Ju-Rui Luo, Yan Feng, Xiao-Li Yu, Xing-Xing Chen, Xiao-Mao Guo
Acta Pharmacol Sin. 2017 Apr; 38(4):513-523. doi: 10.1038/aps.2016.136. Epub 2017 Jan 2.
Gefitinib inhibits M2-like polarization of tumor-associated macrophages in Lewis lung cancer by targeting the STAT6 signaling pathway
Muhammad Tariq, Jie-Qiong Zhang, Gui-Kai Liang, Qiao-Jun He, Ling Ding, Bo Yang
Acta Pharmacol Sin. 2017 Nov; 38(11):1501-1511. doi: 10.1038/aps.2017.124. Epub 2017 Oct 12.
Preclinical evaluation of the efficacy, pharmacokinetics and immunogenicity of JS-001, a programmed cell death protein-1 (PD-1) monoclonal antibody
Jie Fu, Fang Wang, Li-Hou Dong, Jing Zhang, Cheng-Lian Deng, Xue-Li Wang, Xin-Yao Xie, Jing Zhang, Ruo-Xian Deng, Li-Bo Zhang, Hai Wu, Hui Feng, Bo Chen, Hai-Feng Song
Acta Pharmacol Sin. 2017 May; 38(5):710-718. doi: 10.1038/aps.2016.161. Epub 2017 Mar 20.
Enhanced intracellular delivery and controlled drug release of magnetic PLGA nanoparticles modified with transferring
Yan-Na Cui, Qing-Xing Xu, Pooya Davoodi, De-Ping Wang, Chi-Hwa Wang
Acta Pharmacol Sin. 2017 Jun; 38(6):943-953. doi: 10.1038/aps.2017.45. Epub 2017 May 29.
Polydatin ameliorates Staphylococcus aureus-induced mastitis in mice via inhibiting TLR2-mediated activation of the p38 MAPK/NF-kappa B pathway
Kang-Feng Jiang, Gan Zhao, Gan-Zhen Deng, Hai-Chong Wu, Nan-Nan Yin, Xiu-Ying Chen, Chang-Wei Qiu, Xiu-Li Peng
Acta Pharmacol Sin. 2017 Feb; 38(2):211-222. doi: 10.1038/aps.2016.123. Epub 2016 Nov 28.
miRNAS in cardiovascular diseases: potential biomarkers, therapeutic targets and challenges
Shan-Shan Zhou, Jing-Peng Jin, Ji-Qun Wang, Zhi-Guo Zhang, Jonathan H Freedman,Yang Zheng, Lu Cai
Acta Pharmacol Sin. 2018 Jul; 39(7):1073-1084. doi: 10.1038/aps.2018.30.
Exosomes: new molecular targets of diseases
Saheli Samanta, Sheeja Rajasingh, Nicholas Drosos, Zhigang Zhou,Buddhadeb Dawn, Johnson Rajasingh
Acta Pharmacol Sin. 2018 Apr; 39(4):501-513. doi: 10.1038/aps.2017.162.
Chimeric antigen receptor (CAR)-transduced natural killer cells in tumor immunotherapy
Yuan Hu, Zhi-Gang Tian, Cai Zhang
Acta Pharmacol Sin. 2018 Feb; 39(2):167-176. doi: 10.1038/aps.2017.125.
Overview of the anti-inflammatory effects, pharmacokinetic properties and clinical efficacies of arctigenin and arctiin from Arctium lappa L
Qiong Gao, Mengbi Yang, Zhong Zuo
Acta Pharmacol Sin. 2018 May; 39(5):787-801. doi: 10.1038/aps.2018.32.
Insights into molecular therapy of glioma: current challenges and next generation blueprint
Y Rajesh, Ipsita Pal, Payel Banik, Sandipan Chakraborty, Sachin A Borkar, Goutam Dey, Ahona Mukherjee, Mahitosh Mandal
Acta Pharmacol Sin. 2017 May; 38(5):591-613. doi: 10.1038/aps.2016.167.
Exosomal cargo-loading and synthetic exosome-mimics as potential therapeutic tools
Song-Pei Li, Zhong-Xiao Lin, Xue-Yan Jiang, Xi-Yong Yu
Acta Pharmacol Sin. 2018 Apr; 39(4):542-551. doi: 10.1038/aps.2017.178.
Circular noncoding RNAs as potential therapies and circulating biomarkers for cardiovascular diseases
Ahmed S Bayoumi, Tatsuya Aonuma, Jian-Peng Teoh, Yao-Liang Tang, Il-Man Kim
Acta Pharmacol Sin. 2018 Jul; 39(7):1100-1109. doi: 10.1038/aps.2017.196.
The circulating non-coding RNA landscape for biomarker research: lessons and prospects from cardiovascular diseases
Stępień E, Marina C Costa, Szczepan Kurc, Anna Drożdż, Nuno Cortez-Dias, Francisco J Enguita
Acta Pharmacol Sin. 2018 Jul; 39(7):1085-1099. doi: 10.1038/aps.2018.35.
Non-coding RNAs as biomarkers for acute myocardial infarction
Chen Wang , Qing Jing
Acta Pharmacol Sin. 2018 Jul; 39(7):1110-1119. doi: 10.1038/aps.2017.205.
Importance of integrating nanotechnology with pharmacology and physiology for innovative drug delivery and therapy - an illustration with firsthand examples
Rui Xue Zhang, Jason Li, Tian Zhang, Mohammad A Amini, Chunsheng He, Brian Lu, Taksim Ahmed, HoYin Lip, Andrew M Rauth, Xiao Yu Wu
Acta Pharmacol Sin. 2018 May; 39(5):825-844. doi: 10.1038/aps.2018.33.
Zinc deficiency and cellular oxidative stress: prognostic implications in cardiovascular diseases
Sangyong Choi, Xian Liu, Zui Pan
Acta Pharmacol Sin. 2018 Jul; 39(7):1120-1132. doi: 10.1038/aps.2018.25.
APS Outstanding Reviewer Award
Meng, Ling-hua | Jiang, Wei | Cai, Lu | Qi, Qi |
Lu, Jin-Jian | Tang, Wei | Yang, Baoxue | Liu, Shuwen |
Chen, Chun-Jung | He, Xian-hui | Lu, Limin | Sun, Wu-Yi |
Li, Yi-gang | Zhu, Hong | Chen, Yi | Lu, Ming |
Min, Yuanzeng | Ying, Zheng | Duan, Wei-xun | Chen, Shu-zhen |
Pan, Li-Long | Huang, Yongzhuo | Hu, Wei-wei | Gao, Huile |
Pan, Jingxuan | Wen, Fu-Qiang | Yuan, Tifei | Liu, Bo |
Chen, Jun | Shan, Zhi-xin | Wan, Guohui | Wu, Jian |
Cheng, Yan | Hung, Ming-Shiu | Qian, Feng | Sun, Yang |
Hu, Shijun | Liu, Zu-long | He, Xin | Hung, Jan-jong |
APS Outstanding Guest Editor Award
Zhen, Xue-chu | |
Yu, Hai-jun |